Pulsed Ultrasound Assisted Thermo-Therapy for Subsurface Tumor Ablation: A Numerical Investigation

Abstract High-intensity focused ultrasound (HIFU) is a promising therapy for thermal ablation and hyperthermia, characterized by its non-invasiveness high penetration depth. Effective HIFU thermo-therapy requires the ability to accurately predict temperature elevation corresponding dose distribution in target tissues. We report parametric numerical study of response soft tissue ultrasound. compared predictions models with two, three, seven layers, ultrasound-induced heating at duty cycles ranging from 0.6 0.9. Further, two tumor sizes transducer powers (10 W 15 W) were considered. The inhomogeneous Helmholtz equation was coupled Pennes bio-heat pulsed Necrotic lesion size calculated using cumulative equivalent minute (CEM) function. In-vitro experiments performed agar-based phantoms as preliminary validation results. simulations conducted seven-layered model predicted up 33.5% lower peak pressure amplitude than three-layered model. As pulse width decreased sonication time fixed, magnitude rate rise decreased. Pulsed resulted increased volume necrotic lesions an sonication. findings this highlight dependence HIFU-induced on geometry acoustic properties could help guide choice suitable exposure parameters further studies.